miR-214在老年急性心肌梗死患者血清中的表达及其临床意义

Expression and clinical significance of serum miR - 214 in elderly patients with myocardial infarction

目的 研究miR-214在老年急性心肌梗死（AMI）患者血清中的表达，并探究其表达的临床意义。方法 随机选取2016-01-2018-01我院收治的AMI患者73例，不稳定型心绞痛（UA）患者49例，并选择同期在我院体检的健康老人29例作为对照，对比三组研究对象血清miR-214的相对表达量，采用Pearson法分析老年AMI血清miR-214表达与血清天门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）和肌酸激酶同工酶（CK-MB）及心肌肌钙蛋白I（cTnI）的相关性。结果 老年AMI、UA患者和健康体检老人血清miR-214相对表达量分别为14.16±4.13、4.51±2.02和2.07±0.99；在老年AMI患者血清中，miR-214相对表达量与miR-214相对表达量与血清AST（r=0.429，P〈0.05）、CK-MB（r=0.844，P〈0.05），cTnI（r=0.779，P〈0.05）及LDH含量均呈正相关（r=0.562，P〈0.05）。结论 miR-214在老年AMI患者血清中高表达，其高表达可能与心肌损伤或者坏死有关。

Objective To study the expression and clinical significance of serum miR -214 in elderly patients with acute myocardial infarction （AMI）. Methods There were 73 AMI patients, 49 unstable angina （UA） patients and 29 healthy people being chosen in this study from January 2016 to March 2018 in our hospital. The expression of serum miR -214 of the three groups were contrasted, and the correlation between serum miR- 214 of elderly AMI patients and AST, LDH, CK- MB, cTnI were analyzed by Pearson analysis. Results The relative expression levels of miR - 214 in aged AMI patients, UA patients and healthy subjects were 14.16 ± 4.13, 4.51 ± 2.02 and 2.07 ± 0.99. There were positively correlated between the expression of miR - 214 in serum of AMI and AST （ r = 0.429, P〈0.05）, CK-MB （r =0.844,P〈0.05）, cTnI （r =0.779,P〈0.05）, LDH （r =0.562,P〈 0.05）. Conclusion miR- 214 is highly expressed in serum of elderly patients with acute myocardial infarction, and the high expression may be associated with myocardial damage or necrosis.