G蛋白偶联受体与肝损伤的研究现状

Current status of regulation roles of G protein-coupled receptors in liver injury

G蛋白偶联受体(GPCRs)是涉及信号转导的细胞膜最大的受体超家族,介导产生多种生理效应,激活相应的信号级联系统,在肝损伤过程中发挥关键作用,是一类非常重要的药物作用靶标。该文就肾上腺素受体、血管紧张素受体、趋化因子受体、蛋白酶激活受体等参与急慢性肝损伤调节的GPCRs相关研究进展做一综述。

The G protein-coupled receptors（ GPCRs） superfamily,represents the largest class of molecules involved in signal transduction across the plasma membrane. GPCRs regulate physiological responses to a diverse array of stimuli and mediate multiple physiological processes.As a consequence of this,the potential of GPCRs-based therapeutics being used for liver damage is highlighted. Therefore,this article summarizes the role of GPCRs（ including adrenergic receptor, angiotensin receptor,chemokine receptor and endothelin receptor） in acute-and chronic-liver injury.