肿瘤微环境对肿瘤血管生成的影响

Effects of tumor microenvironment on tumor angiogenesis

肿瘤微环境是一个动态的网络,它由多种类型的细胞(如肿瘤细胞、血管内皮细胞、成纤维细胞、免疫细胞和周细胞等)以及细胞外成分(如细胞因子、生长因子和细胞外基质等)组成。肿瘤微环境对肿瘤发展的影响日益引人注目。另一方面,肿瘤血管生成是实体肿瘤生长、浸润和转移的标志,越来越多的研究表明其与肿瘤微环境密切相关,但确切机制尚未探明。本文详细解析肿瘤微环境对肿瘤血管生成的影响,以期为抗肿瘤血管生成研究提供更广阔的思路。

The tumor microenvironment is a dynamic network, which includes various types of cells （such as tumor cells, vascular endothelial cells, fibroblasts, immune cells, and pericytes） and extracellular components （such as cytokines, growth factors, and extracellular matrix）. The impact of tumor microenvironment on the development of tumor is becoming more and more attractive. Tumor angiogenesis is a hallmarker in growth, invasion and metastasis of solid tumor. More and more studies show that tumor angiogenesis is closely related to tumor microenvironment, but the precise mechanism is still unclear. In this review, the effect of tumor microenvironment on tumor angiogenesis is analyzed in detail, so as to provide a broader thinking for anti-tumor angiogenesis research.