摘要
锰作为一种人体必不可少的微量营养素,参与机体的骨矿化、蛋白质和能量代谢、代谢调节等,在正常生长发育特别是大脑的发育中起着至关重要的作用,但是当机体摄入剂量超过锰稳态时可能会产生神经毒性。近年研究显示,孕期过量锰水平会对儿童的神经发育及行为产生消极作用。本文从孕期锰过量与儿童神经发育比如运动能力、认知功能发育和行为问题和锰诱导神经毒性的机制两方面进行综述,探讨孕期锰过量对儿童运动、认知及行为发育的影响,并提出未来应努力探索一种稳定、准确并被普遍认可的生物标志物来降低不可控因素增加研究的可比性。
As a micronutrient essential element involved in bone mineralization, protein and energy metabolism, metabolic regulation, manganese plays a vital role in normal growth and development, especially in brain development. Neurotoxicity of manganese occurs when the intake dose exceeds manganese homeostasis. Recent studies have shown that excessive levels of manganese during pregnancy can negatively affect neurodevelopment and behavior in children.This paper reviews the studies on the relationship between maternal manganese exposure during pregnancy and children neurodevelopment, such as motor ability, cognitive function, and behavior problems, as well as possible mechanism of manganese induced neurotoxicity, and suggests that future efforts should be made to explore stable, accurate and widely recognized biomarkers to reduce the uncontrollable factors and increase the comparability of relevant researches.
作者
张保丽
陶芳标
ZHANG Bao-li;TAO Fang-biao(Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province 230032, Chin)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2018年第4期620-624,共5页
Chinese Journal of Public Health
基金
国家自然科学基金(81330068)
关键词
锰
儿童
运动技巧
认知
行为
神经发育
manganese
children
motor ability
cognition
behavior
neurodevelopment