早发性卵巢功能不全的临床诊治进展

Clinical research advances on premature ovarian insufficiency

早发性卵巢功能不全(POI)是指在妇女40岁之前卵巢功能明显衰退或丧失的临床综合征,严重影响女性生育健康及身心健康。POI病因包括遗传性因素、免疫性因素、医源性因素等,但大多数患者病因仍不明确,其具体发病机制仍有待进一步研究。POI患者的生育能力明显下降,但目前尚无改善POI生育力的有效方法,激素补充治疗(HRT)是预防和治疗继发于POI的各系统并发症的有效手段。近年来,国内外研究提供许多新的依据,但是尚存许多未解之谜,本文将主要对POI的临床进展进行综述。

Premature ovarian insufficiency （POI） is a clinical syndrome manifested with significant decline or loss of ovarian activity before the age of 40 years, which has serious effects on the reproductive, physical and mental health of women. The causes of POI are involved with genetic factors, immunological factors and iatrogenic factors, and the eti- ology of most patients remains unclear. The fertility of POI patients dramatically decreases, but there is no satisfactory treatment so far. Hormone replacement therapy （HRT） is considered an effectively preventative and therapeutic option to manage complications related to POI. Although many researchers have focused on the mechanism, diagnosis and treat- ment of POI in recent years, much remains to be explored. This article will review the clinical research advances on POI.