慢性鼻-鼻窦炎的内在型:从基础到临床

Endotype of chronic rhinosinusitis: from basic to clinical research

慢性鼻-鼻窦炎(CRS)是多因素作用下鼻及鼻窦黏膜的慢性持续性炎症,具有高度异质性,病理机制非常复杂,临床表现型相同,其内在型和预后可能不同。CRS内在型是对不同个体CRS发病内在本质的研究,是从细胞和分子生物学角度探索疾病的发病本质,随着CRS内在型研究的不断深入,期望能找到某些特定的分子标志物,以这些分子标志物为靶标实现个体化的精准治疗。

Chronic rhinosinusitis （CRS） is a complex disease that involves multiple factors and is characterized by chronic persistent inflammation of the nasal and sinus mucosa. Owing to the high heterogeneity and complicated pathological mechanism, polyps of different endotypes may exhibit the same phenotype. The present research on the endotype of chronic rhinosinusitis focuses on the cellular and molecular biology aspects of the disease onset. We expect to identify specific molecular markers, which can be used as target molecules for accurate individualized treatment.