摘要
目的研究雷公藤200℃烘箱煨制后化学成分含量变化,探讨雷公藤煨制减毒增效机制。方法分别以雷公藤甲素、雷公藤红素和雷公藤次碱为对照,用紫外-可见分光光度法测定雷公藤总二萜、总三萜及总生物碱的含量。结果雷公藤药材煨制后总二萜、总三萜和总生物碱的含量显著下降,降幅均超过7%,其中总生物碱降幅最大,达28.40%。结论雷公藤煨制后对其化学成分有显著影响,其煨制减毒增效可能主要与生物碱类成分变化有关。
OBJECTIVE To study on the constituent change of Tripterygium wilfordii after roasting processing at 200℃ and disclose the mechanism involving reducing toxicity and enhancing efficacy. METHODS The content of total diterpenoids,triterpenes and alkaloids were determined by UV-Vis spectrophotometry using triptolide, celastrol and wilforine as the control. RESULTS The content of total diterpenes,triterpenes and alkaloids decreased signifi- cantly after processing. The decrease was all over 7% ,and the total alkaloids dropped the largest ,reaching 28.40%. CONCLUSION The chemical constituents of Tripterygium wilfordii significantly changed after processing. The mechanism involving reducing toxicity and enhancing efficacy manly associated with the decrease of total alkaloids.
作者
刘建群
罗素花
杨瑞昆
舒积成
张锐
LIU Jian-qun;LUO Su-hua;YANG Rui-kun;SHU Ji-cheng;ZHANG Rui(Key Laboratory of Modern Prepa- ration of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Chin)
出处
《海峡药学》
2018年第4期38-40,共3页
Strait Pharmaceutical Journal
基金
江西省自然科学基金项目(20151BAB205075)
江西省教育厅科技项目(GJJ150832)
关键词
雷公藤
煨制
总二萜
总三萜
总生物碱
Tripterygium wilfordii
total diterpene
total triterpene
total alkaloid
