补本解郁颗粒剂治疗冠心病经皮冠状动脉介入术后脾肾两虚型心绞痛的临床疗效

Clinical Effect of Buben-jieyu Granules on Angina Pectoris(TCM Spleen-kidney Deficiency Syndrome) in Postoperative Coronary Heart Disease Patients Treated by PCI

目的观察补本解郁颗粒剂治疗冠心病经皮冠状动脉介入术(PCI)后脾肾两虚型心绞痛的临床疗效。方法选取2016年10月—2017年10月南京中医药大学附属江苏省中西医结合医院心血管内科收治的冠心病PCI后脾肾两虚型心绞痛患者60例,采用随机数字表法分为对照组与治疗组,每组30例。在常规治疗基础上,对照组患者予以中药颗粒安慰剂,治疗组患者予以补本解郁颗粒剂;两组患者均连续治疗28 d。比较两组患者临床疗效、治疗前后血脂指标、硝酸甘油停减率,并观察两组患者治疗期间不良反应发生情况。结果治疗组患者临床疗效优于对照组(P<0.05)。治疗前两组患者总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后两组患者TC、TG、HDL-C水平比较,差异无统计学意义(P>0.05),而治疗组患者LDL-C水平低于对照组,差异有统计学意义(P<0.05);两组患者治疗后TC、TG、LDL-C水平低于治疗前(P<0.05)。治疗组患者硝酸甘油停减率高于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论补本解郁颗粒剂治疗冠心病PCI后脾肾两虚型心绞痛的临床疗效确切,可有效改善患者血脂代谢,减少硝酸甘油用量,且安全性较高。

Objective To observe the clinical effect of buben-jieyu granules on angina pectoris （TCM spleen-kidney deficiency syndrome） in postoperative coronary heart disease patients treated by PCI. Methods From October 2016 to October 2017, a total of 60 postoperative coronal7 heart disease-induced angina pectoris （TCM spleen-kidney deficiency syndrome） patients treated by PCI were selected in the Department of Cardiovascular Medicine, Jiangsu Province Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, and they were divided into control group and treatment group according to random number table, each of 30 cases. Based on conventional treatment, patients in control group received placebo （Chinese medicine granules）, while patients in treatment group received buben-jieyu granules; both group continuously treated for 28 days. Clinical effect, blood lipids index before and after treatment, discontinuation or decrement rate of nitroglycerin, and incidence of adverse reactions during treatment were compared between the two groups. Results Clinical effect in treatment group was statistically significantly better than that in control group （P〈0.05）. No statistically significant differences of TC, TG, HDL-C or LDL-C was found between the two groups before treatment, nor was TC, TG or HDL-C after treatment （P〉0.05）, while LDL-C in treatment group was statistically significantly lower than that in control group （P〈0.05）; after treatment, TC, TG and LDL-C in the two groups were statistically significantly lower than those before treatment （P〈0.05）. Discontinuation or decrement rate of nitroglycerin in treatment group was statistically significantly higher than that in control group （P〈0.05）. No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment （P〉0.05）. Conclusion Buben-jieyu granules has certain clinical effect in treating angina peetoris （TCM spleen-kidney deficiency syndrome） in postoperative coronary heart disease patients treated by PCI, can effectively adjust the blood lipid metabolism, reduce the dosage of nitroglycerin, and is relatively safe.