疏血通注射液联合多巴丝肼片治疗帕金森病的临床疗效

Clinical Effect of Shuxuetong Injection Combined with Benserazide-levodopa Tablets on Parkinson's Disease

目的观察疏血通注射液联合多巴丝肼片治疗帕金森病(PD)的临床疗效。方法选取2016年6月—2017年1月解放军第九七医院收治的PD患者102例,采用随机数字表法分为联合组与常规组,每组51例。常规组患者予以多巴丝肼片治疗,联合组患者在常规组基础上加用疏血通注射液治疗;两组患者均连续治疗30 d。比较两组患者临床疗效及治疗前后帕金森病统一评分量表(UPDRS)评分、病重侧局部脑血流量(r CBF)、5-羟色胺(5-HT)水平,并观察两组患者治疗期间不良反应发生情况。结果联合组患者临床疗效优于常规组(P<0.05)。治疗前两组患者UPDRS评分比较,差异无统计学意义(P>0.05);治疗后联合组患者UPDRS评分低于常规组(P<0.05)。治疗前两组患者病重侧额叶、枕叶、基底核、小脑r CBF比较,差异无统计学意义(P>0.05);治疗后联合组患者病重侧额叶、枕叶、基底核、小脑r CBF大于常规组(P<0.05)。治疗前两组患者5-HT水平比较,差异无统计学意义(P>0.05);治疗后联合组患者5-HT水平高于常规组(P<0.05)。联合组患者治疗期间不良反应发生率低于常规组(P<0.05)。结论疏血通注射液联合多巴丝肼片治疗PD的临床疗效确切,可有效改善患者运动功能、脑血流灌注,提高5-HT水平,减少不良反应的发生。

Objective To observe the clinical effect of Shuxuetong injection combined with benserazide-levodopa tablets on Parkinson＇s disease. Methods A total of 102 patients with Parkinson＇s disease were selected in the 97 th Hospital of the Chinese People＇s Liberation Army from June 2016 to January 2017, and they were divided into convention group and combination group according to random number table, each of 51 cases. Patients in convention group received benserazide-levodopa tablets, while patients in combination group received Shuxuetong injection combined with benserazide-levodopa tablets; both groups continuously treated for 30 days. Clinical effect, UPDRS score, badly affected side regional cerebral blood flow（r CBF） and 5-HT before and after treatment were compared between the two groups, and incidence of adverse reactions was observed during treatment. Results Clinical effect in combination group was statistically significantly better than that in convention group（P〈0.05）. No statistically significant differences of UPDRS score was found between the two groups before treatment（P〉0.05）, while UPDRS score in combination group was statistically significantly lower than that in convention group after treatment（P〈0.05）. No statistically significant differences of badly affected side r CBF of frontal lobe, occipital lobe, basal nuclei or cerebellum was found between the two groups before treatment（P〉0.05）, while badly affected side r CBF of frontal lobe, occipital lobe, basal nuclei and cerebellum in combination group were statistically significantly higher than those in convention group after treatment（P〈0.05）. No statistically significant differences of 5-HT was found between the two groups before treatment（P〉0.05）, while 5-HT in combination group was statistically significantly higher than that in convention group after treatment（P〈0.05）. Incidence of adverse reactions in combination group was statistically significantly lower than that in convention group during treatment（P〈0.05）. Conclusion Shuxuetong injection combined with benserazide-levodopa tablets has certain clinical effect in treating patients wiht Parkinson＇s disease, can effectively improve the motor function, cerebral blood flow perfusion and 5-HT, reduce the risk of adverse reactions.