配合物与核酸相互作用的研究进展

Advances in the Interaction of Complexes with Nucleic Acids

人体端粒是由富含鸟嘌呤(G)的序列组成,该序列在一定条件下可以形成G-四链体结构。G-四链体的基本结构单元是G-四分体,G-四分体是由四个鸟嘌呤残基通过Hoogsteen氢键首尾连接而成的芳香平面环状结构。G-四链体除了存在于端粒处,还存在于许多其他基因中(例如启动子区域)。G-四链体可以抑制端粒酶的活性,即端粒酶不能延长端粒,从而抑制了癌细胞的增殖。目前,有机小分子已经被报道可以通过多种结合模式稳定G-四链体。相比而言,配合物作为G-四链体稳定剂显现出来的优势是有机小分子所无法比拟的。总结,作为G-四链体稳定剂的配合物可以分为三大类:(1)以大环平面分子为配体的配合物;(2)以非大环平面分子为配体的配合物;(3)其他类型的配合物。本论文将综述配合物作为G-四链体稳定剂的研究进展。

Human telomeres are composed of guanine （G）-rich sequences, which can form G-quadruplex （GQ） structures in certain conditions. The structural unit of the GQ is G-tetrad, the G-tetrad is an aromatic planar ring structure in which four guanine residues are linked one by one through Hoogsteen hydrogen bonds. Compared to organic small molecules, metal complexes as GQ stabilizers are showing various advantages. We divide the complexes into three categories： （1） complexes with macrocyclic plane molecules as ligands, （2） complexes with non-macrocyclic plane molecules as ligands, （3） other types of complexes. This paper will review the progress of complexes as GQ stabilizers.