摘要
糖皮质激素(GC)在自身免疫性疾病的治疗中发挥重要作用,其诱导的骨质疏松症(GIOP)为治疗引起的主要不良反应。由于对GIOP缺乏充分认知,很多长期服用GC的患者未进行及时合理的预防及治疗。根据相关文献及最新指南,重点介绍了GIOP的发病率、发生机制、危险因素及防治方法,为临床防治GIOP提供参考。
Glucocorticoid （GC） plays an important role in the treatment of many autoimmune diseases. Glucocorticoid-indueed osteoporosis （GIOP） is one of the major adverse effects of GC therapy. Due to the lack of full understanding of GIOP, prompt and appropriate prevention and treatment are not available to many patients receiving long-term GC therapy. This article mainly discusses epidemiology, mechanism, risk factors and the treatment program of GIOP based on the latest GIOP-related guideline and literature, so as to provide a reference for prevention and treatment of GIOP in clinical practice.
作者
葛泳含
束庆
葛卫红
GE Yonghan;SHU Qing;GE Weihong(Department of Pharmacy, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China;School of Integrated Chinese Traditional and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, China)
出处
《药学进展》
CAS
2018年第3期170-176,共7页
Progress in Pharmaceutical Sciences
基金
南京市医学科技发展基金(No.QRX17140)
关键词
糖皮质激素
骨质疏松
骨折风险
防治
glucocorticoid
osteoporosis
fractures risk
prevention and treatment
