膦甲酸钠氯化钠注射液联合泛昔洛韦片治疗头面部带状疱疹的临床观察

Clinical observation of foscarnet sodium and sodium chloride injection combined with famciclovir in the treatment of head herpes zoster

观察静滴膦甲酸钠氯化钠注射液联合口服泛昔洛韦片对治疗头面部带状疱疹的临床疗效及安全性。本文将98例头面部带状疱疹患者分为对照组48例与治疗组50例,观察口服泛昔洛韦片(对照组)和口服泛昔洛韦片联合静滴膦甲酸钠氯化钠注射液(治疗组)治疗头面部带状疱疹的临床疗效及安全性。根据复诊或随访比较两组患者的疗效评价参数,分析得出治疗组总有效率(96.0%)明显优于对照组(79.2%,P<0.05);治疗组在止痛、结痂、脱痂时间方面显著优于对照组(P<0.05)。在治疗头面部带状疱疹中,应用膦甲酸钠氯化钠注射液联合泛昔洛韦片,可较快使得疼痛缓解、皮损减少,安全性高且疗效佳,值得临床推广。

In this study,98 cases of head-to-face herpes zoster patients were divided into the control group（48 cases）and the treatment group（50 cases） to observe the clinical efficacy and safety of oral famciclovir tablets and oral famciclovir tablets combined with intravenous sodium infusion of intravenous drip Phosphate sodium for the treatment of head-to-face herpes zoster.According to the follow-up comparison of the efficacy evaluation parameters of the two groups,the total effective rate of the treatment group was 96.0%,which was significantly better than that of the control group（79.2%）（P〈0.05）;The group had significantly better pain relief,scarring,and dislocation time than the control group. The difference was statistically significant（P〈0.05）,and there was no significant difference in the time to stop snoring（P〈0.05）. In the treatment of head-to-face herpes zoster,the use of sodium folinate sodium chloride injection combined with famciclovir tablets,can make the pain relief,skin lesions reduce faster,with high safety and good efficacy,which is worth clinical promotion.