异甘草酸镁辅助糖皮质激素治疗胆道探查术后继发毛细胆管炎的临床疗效

Efficacy of Magnesium isoglycyrrhizinate assisted glucocorticoid therapy on the cholangiolitis after bile duct exploration after operation

为了探讨异甘草酸镁辅助糖皮质激素治疗胆道探查术后继发毛细胆管炎的临床疗效,回顾分析88例胆道探查术后继发毛细胆管炎患者的完整临床资料,以采用糖皮质激素治疗为对照组,异甘草酸镁辅助糖皮质激素治疗为治疗组,每组44例。比较两组患者的血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清总胆红素(TBil)、碱性磷酸酶(ALP)、血流变学指标。结果显示,与治疗前相比,两组治疗后ALT、AST、TBil、ALP、全血低切黏度、血浆黏度、血小板聚集率均有所下降,且治疗组上述指标下降幅度较大。治疗组的总有效率为81.8%,高于对照组的68.2%。异甘草酸镁辅助糖皮质激素治疗胆道探查术后继发毛细胆管炎有良好的临床疗效,能显著改善胆汁淤积性肝炎的临床症状和肝功能指标,安全性良好,值得临床推广。

To evaluate the efficacy of Magnesium isoglycyrrhizinate assisted glucocorticoid therapy after bile duct operation,clinical data of 88 cases with cholangiolitis after bile duct operation were analyzed. The patients treated with glucocorticoid therapy were served as control group,the patients treated with Magnesium isoglycyrrhizinate and glucocorticoid as treatment group,the liver function indexes（AST,TBil,ALT,ALP） and blood rheology indexes were compared.Results showed,compared to treatment before,ALT,AST,TBil,ALP,the whole blood low shear viscosity,plasma viscosity and platelet aggregation rate were significantly decreased after treated with drugs,and the treatment group decreased more than that of the control group. After drug treatment,the total effective rate of 81.8% of the treatment group was higher than that of 68.2% of the control group. These data suggested that Magnesium isoglycyrrhizinate assisted glucocorticoid therapy on the cholangiolitis after bile duct exploration can significantly improve cholestatic hepatitis clinical symptoms and liver function indicators,worthy of clinical promotion.