Urocortin在子宫内膜异位症患者组织及血清中的表达水平及临床意义

The clinical significance of urocortin expression in endometriosis

子宫内膜异位症具有侵袭、复发等恶性行为特征,且存在激素依赖性,Urocortin(UCN)属于促肾上腺皮质激素释放激素,参与血管生成、炎症反应、凋亡及免疫活动调节等,本研究通过免疫组织化学(IHC)、酶联免疫吸附试验(ELISA)实验,探究56例内异症患者组织及血清中UCN表达水平与内异症临床因素之间的关系,结果显示内异症患者在位内膜及异位病灶中UCN的表达强度显著高于正常子宫内膜组织,且与患者疾病分期、病灶大小相关。内异症患者血清UCN水平(54.40±9.12 pg/m L)显著高于正常对照组(21.30±4.72 pg/m L)。提示UCN的表达水平与内异症发生发展密切相关,可能成为内异症早期诊断及预后评估的潜在标志物。

Endometriosis has the characteristics of malignant behavior,such as invasion and recurrence,and there is hormone dependence.Urocortin（UCN） belongs to the corticotropin releasing hormone,involved in angiogenesis,inflammation,apoptosis and immune regulation.This study is to explore the relationship between the expression of UCN in the serum levels of 56 cases of endometriosis patients and clinical factors of endometriosis by immunohistochemistry（IHC） and enzyme-linked immunosorbent assay（ELISA）.The results showed that the intensity of UCN in eutopic endometrium and ectopic lesion of endometiosis was significantly higher than that of normal endometrium tissue.It was also significantly correlated with staging and lesion size. The serum UCN level（54. 40 ± 9. 12 pg/m L） was significantly higher in the endometriosis group than that in the control group（21.30±4.72 pg/m L）.It is suggested that the expression level of UCN was closely related to the development endometriosis.Thus,maybe UCN could be a potential marker for diagnosis and predicting prognosis in patients with endometriosis.