鞍区粘膜相关性B细胞淋巴瘤1例及文献复习

Mucosa associated lymphoid tissue lymphoma in sellar region(report of one case and review of literature)

目的探讨鞍区粘膜相关淋巴组织(mucosa associated lymphoid tissue,MALT)淋巴瘤的临床特点。方法对昆明医科大学第一附属医院近期收治的1例鞍区MALT淋巴瘤患者的临床资料进行回顾性分析;并复习相关文献。结果患者因头痛8个月余入院;头颅MRI检查示:鞍区病变;考虑慢性淋巴细胞性垂体炎并周围感染可能。为进一步明确诊断,显微镜下经鼻蝶鞍区病变取活检。病理检查为鞍区MALT淋巴瘤。予以患者大剂量甲氨蝶呤、阿糖胞苷化疗,联合小剂量放疗3个疗程;6个月后随访无复发。结论鞍区MALT淋巴瘤的临床及影像学表现缺乏特异性,极易误诊。遇到鞍区不典型影像学表现的患者时,要考虑MALT淋巴瘤的可能;争取早发现、早治疗,改善预后。

Objective To explore the clinical characteristics of the sellar area mucosa associated lymphoid tissue,MALT） lymphoma. Methods The clinical data of the patient with sellar area MALT lymphoma in our hospital were analyzed retrospectively and related literatures were reviewed. Results Patients had a headache for 8 months,After admission,head MRI suggested chronic lymphocytic inflammation of the pituitary with peripheral infection. The biopsy of the sella turcica region under microscope was performed for the purpose of definite diagnosis. The pathological findings were sellar region MALT lymphoma. The patient was treated with methotrexate combined with radiotherapy. Conclusion The imaging and clinical manifestations of sellar area MALT lymphoma are lack of specificity and are easily misdiagnosed. When the atypical imaging findings of the sellar region are encountered,the possibility of lymphoma should be considered. Early detection and early treatment can improve prognosis.