摘要
目的通过观察大鼠创面组织修复及成纤维细胞生长因子(FGF)的表达,探讨紫白膏剂对创面愈合的影响及可能机制。方法将40大鼠随机分为紫白膏组、凡士林组各20只,造模后分别予紫白膏、凡士林换药,第3、7、14天观察记录大鼠创面修复情况。取大鼠创面组织做Western-blot检测,观察FGF因子表达情况。结果两组均能提高b FGF表达水平,第14天紫白膏组与凡士林组比较,高于凡士林组,差异有统计学意义(P<0.05)。紫白膏组与凡士林组比较,愈合时间短于凡士林组,差异有统计学意义(P<0.05)。结论紫白膏能有效提高FGF因子的表达并促进大鼠创面的修复。
Objective To investigate the effect of Zibai cream on wound healing and its possible mechanism by observing the repair of wound tissue and the expression of fbroblast growth factor （FGF） in rats. Methods Forty rats were randomly divided into two groups 20 in the zibai cream group and 20 in the vaseline group. After modeling, zibai cream and vaseline was used to dress after modeling. The repair of wounds in rats on the 3rd, 7th, and 14th day was observed and recorded. The wound tissue of rats was taken for Western-blot detection to observe the expression of FGFfactors. Results Two groups both could increase the expression of bFGF. On the 14th day, zibai cream group was significantly higher compared with vaseline group（P 〈 0.05）. The healing time of zibai cream group was shorter than vaseline group. There was a statistical diference （P 〈 0.05）. Conclusion Zibai cream can efectively increase the expression of bFGF factors and promote the repair of wound in rats.
作者
许圳鹏
赵诚
倪虹
XU Zhenpeng;ZHAO Cheng;NI Hong(The Second Department of Anorectal Surgery, The People＇s Hospital Afliated to Fujian University of Traditional Chinese Medicine, Fuzhou Fujian 350004, China;Clinical Laboratory)
出处
《中国卫生标准管理》
2018年第9期107-109,共3页
China Health Standard Management
基金
福建省教育厅科技项目(JA15231)
