海洋生物来源血管紧张素转换酶抑制肽的研究进展

Review on angiotensin converting enzyme inhibitory peptides from marine organisms

血管紧张素转化酶(angiotensin converting enzyme,ACE)抑制剂通过抑制ACE活性能够降低血压。目前人工合成ACE抑制药物已开发并应用到降血压的治疗中,但会带来多种副作用。食源性ACE抑制肽与合成抑制剂相比因其副作用小、安全性高等特点,成为ACE抑制肽研究的热点。由于独特的生活环境与巨大的存在数量,海洋生物具有与陆地生物截然不同的化学结构及丰富的生物活性成分。海洋生物来源ACE抑制肽的研究为食源性ACE抑制肽的筛选提供了基础。本文结合海洋生物来源ACE抑制肽的作用机制及制备流程,对鱼类、软体动物、虾类、藻类及海绵、海蜇、粗刺参等不同生物来源的ACE抑制肽制备工艺进行了综述,并对海洋生物的综合开发利用进行了概括。

Angiotensin converting enzyme（ACE） inhibitors can reduce blood pressure by inhibiting ACE activity. At present, synthetic ACE inhibitors have been developed and applied to the treatment of blood pressure lowering, but will bring many side effects. Compared with synthetic inhibitors, foodborne ACE inhibitory peptides have become a hotspot in the research of ACE inhibitory peptides because of their less side-effects and high safety. Because of its unique living environment and large number of living organisms, marine organisms have distinct chemical structures and abundant bioactive components from terrestrial organisms. The study of ACE inhibitory peptides from marine organisms provides a basis for the screening of foodborne ACE inhibitory peptides. Based on the mechanism and preparation process of ACE inhibitory peptides from marine organisms, this paper reviewed the preparation process of ACE inhibitory peptides from different biological sources, such as fish, molluscs, shrimp, algae and sponges, jellyfish, sea cucumber, etc, and the comprehensive development and utilization of marine organisms were summarized.