预防性应用抗生素对肝硬化上消化道出血患者感染的影响分析

Clinical impact analysis of prophylactic use of antibiotics in patients with liver cirrhosis upper gastrointestinal bleeding infection

目的探讨对肝硬化上消化道出血患者应用抗生素进行预防感染治疗的效果。方法选取2015年1月至2017年1月永城市人民医院收治的104例肝硬化上消化道出血患者作为研究对象,随机将患者分成观察组和对照组各52例。对照组给予常规方法治疗,观察组在对照组的基础上应用抗生素预防感染,统计分析两组患者的感染率,消化道止血所需时间以及再出血的发生率。结果观察组患者的感染率、再出血发生率和病死率分别为21.15%、19.23%、7.69%,明显低于对照组,差异具有统计学意义(P<0.05),两组患者各个部位感染比例差异无统计学意义(P>0.05);观察组患者的住院时间明显短于对照组,差异具有统计学意义(P<0.05)。结论在肝硬化合并上消化道出血患者中预防使用抗生素,能明显降低患者医院感染发生率,降低患者的再出血情况发生率及病死率,缩短患者的住院时间,减轻了患者的经济负担,值得临床推广使用。

Objective To study the use of antibiotics in patients with liver cirrhosis upper gastrointestinal bleeding to analyze the effect of preventing infection treatment,for clinical liver cirrhosis upper gastrointestinal tract infection patients provide theoretical basis for the use of antibiotics. Methods Chose between August 2013 and July 2013 hospital treated104 cases of liver cirrhosis upper gastrointestinal hemorrhage patients as the research object,according to the order of patients admitted to hospital patients on average can be divided into two groups,the observation group and the control group each 52 cases. Given control group routine treatment,given the observation group on the basis of the control group application of antibiotics for preventing infection treatment,statistical analysis of two groups of patients with infection rates,time needed for gastrointestinal bleeding and the incidence of appeared again. Results In observation group,the infection rate was significantly higher than that of the control group,and significant difference between the two groups has statistical significance（P〈0. 05）; Two groups of patients with various parts of the proportion of infections compared,did not differ significantly; observation group of patients with rebleeding incidence rate and mortality rate were significantly lower than the control group and between the two groups difference has statistical significance（P〈0. 05）; observation group patients hospitalization time was significantly shorter than that of the control group,between the two groups significantly different,with statistical significance（P〈0. 05）. Conclusion In patients with hepatocirrhosis with upper gastrointestinal hemorrhage preventive use of antibiotics,can significantly reduce the incidence of hospital infection in patients with,decrease the incidence of bleeding again,decrease case fatality rate,shorten the hospitalization time of patients and reduce the economic burden of patients,and is worth wide use in the clinical.