对氨基水杨酸钠和力克肺疾在258株耐异烟肼结核分枝杆菌中的交叉耐药情况

The cross drug resistant results of sodium aminosalicylate and dipasic in 258 cases of isoniazid resistant of Mycobacterium tuberculosis

目的探讨和分析抗结核药物对氨基水杨酸钠和力克肺疾在耐异烟肼结核分枝杆菌中的交叉耐药情况。方法应用MGIT960液体快速培养法联合绝对浓度法测定含结核分枝杆菌临床样本对异烟肼、对氨基水杨酸钠和力克肺疾的耐药情况,通过统计软件分析3种抗结核药物的交叉耐药情况。结果对258例耐低浓度异烟肼的结核分枝杆菌临床样本进行分析,年龄<40岁的病人耐药比例占总数的49.61%。对氨基水杨酸钠和力克肺疾均以低浓度耐药为主,耐药率分别为41.86%和35.66%。3种药物交叉耐药分析结果显示,同时耐3种高浓度药物所占比率最高,占交叉耐药总数的28.24%,其中对高浓度的异烟肼、对氨基水杨酸钠和力克肺疾与其在总体中的耐药比例相比,分别升高了19.95%、44.98%和22.90%(P<0.05)。结论抗结核药物对氨基水杨酸钠和力克肺疾在耐异烟肼的结核分枝杆菌中出现了明显的交叉性耐药,希望引起临床医生和相关部门的高度重视。

Objective To investigate and analysis the cross drug resistant results of sodium aminosalicylate and dipasic in isoniazid resistant of Mycobacterium tuberculosis. Methods Used MGIT960 liquid culture and absolute concentration method to explore the drug resistant results,and analysed the cross drug resistant results of Mycobacterium tuberculosis clinical samples by statistical software. Results Analysed 258 cases of low concentrations of isoniazid resistant Mycobacterium tuberculosis clinical samples,the resistance proportion under 40 years accounted for 49. 61%. The major drug resistance rate of sodium aminosalicylate and dipasic were low concentration,which were 41. 86% and 35. 66%. The results showed that the resistance to three kinds of high concentration drugs accounted for the highest,was 28. 24% of the total number of cross resistance. Compared with the overall drug resistance,the high concentrations resistant level of isoniazid,sodium aminosalicylate and dipasic was increased by19. 95%,44. 98% and 22. 90%（ P〈0. 05）. Conclusion We find that sodium aminosalicylate and dipasic has been formed clear crossover resistance in isoniazid resistant of Mycobacterium tuberculosis,hoping to attract the attention of clinicians and related departments.