多种西药联合应用的临床不良反应分析及其应对措施

Clinical Adverse Reaction Analysis and Countermeasures of Various Western Drugs

目的为有效提高临床用药安全性,探讨多种西药联合应用的临床不良反应及其应对措施。方法选取本院于2015年7月至2018年1月入院进行多种西药联合治疗的154例患者作为研究对象,按照双盲对照原则进行分组,对照组(n=77)患者不予以任何用药干预,研究组(n=77)患者采取用药情况干预。比较两组不良反应情况,并分析其应对措施。结果不良配伍、重复用药、用法不当及剂量不当均可作为引发不良反应的主要原因。恶心呕吐、头晕、皮疹、失眠为主要不良反应,对照组的不良反应总发生率(19.48%)显著高于研究组(7.79%),组间数据差异有统计学意义(P<0.05)。结论通过科学使用药物,降低不良反应发生率,达到提高多种药物联用的安全性的目的。

Objective In order to effectively improve the safety of clinical medication, to explore the clinical adverse reactions combined with a variety of western medicine and its countermeasures. Methods A total of 154 patients admitted to our hospital from July 2015 to January 2018 undergoing multiple western medicine combinations were selected according to the double-blind control principle. The patients in the control group（n=77） were not given any medication Interventions, study group（n=77） patients taking medication intervention. Adverse reactions were compared between the two groups and their coping strategies were analyzed. Results Poor compatibility, repeated medication, improper use and improper dosage can be used as the main cause of adverse reactions. Nausea and vomiting, dizziness, rash and insomnia were the main adverse reactions. The total adverse reaction rate（19.48%） in the control group was significantly higher than that in the study group（7.79%）. There was significant difference between the two groups（P〈0.05）. Conclusion Through the scientific use of drugs, reduce the incidence of adverse reactions, to improve the safety of a variety of drugs combined purposes.