妊娠期糖尿病孕早中期脂肪细胞因子Chemerin、RBP4水平的研究

Study on the Levels of Adipocytokines Chemerin and RBP4 in Gestational

目的研究妊娠期糖尿病孕早中期脂肪细胞因子Chemerin、RBP4的水平。方法选择2016年10月-2017年10月医院接收的妊娠期糖尿病孕妇52例作为观察组,同期选择医院接收的非妊娠期糖尿病正常孕妇52例作为对照组。分别在孕早期和孕中期,对两组孕妇进行血液检查,对比脂肪细胞因子中Chemerin、RBP4水平。结果孕早期,观察组孕妇Chemerin(77.3±7.2)ng/mL,RBP4(50.9±5.1)ug/mL,高于对照组孕妇(P<0.05);孕中期,观察组孕妇Chemerin(232.6±25.1)ng/mL,RBP4(55.8±12.6)ug/mL,高于对照组孕妇(P<0.05)。结论在孕早中期,妊娠期糖尿病与非妊娠期糖尿病孕妇,在脂肪细胞因子Chemerin、RBP4水平上有显著差异,提示该因子与妊娠期糖尿病的发病存在联系。

Objective To study the levels of adipocytokines Chemerin and RBP4 during the first trimester of gestational diabetes mellitus. Methods 52 cases of pregnant women with gestational diabetes mellitus received from the hospital from October 2016 to October 2017 were selected as the observation group. 52 pregnant women with non-gestational diabetes mellitus received by the hospital during the same period were selected as the control group. Blood tests were performed on the two groups of pregnant women during the first trimester and the second trimester to compare the levels of Chemerin and RBP4 in adipocytokines. Results In the first trimester of pregnancy, Chemerin（77.3±7.2） ng/mL and RBP4（50.9±5.1） ug/mL in the observation group were significantly higher than those in the control group（P〈0.05）） ng/mL, RBP4（55.8±12.6） ug/mL, higher than the control group pregnant women（P〈0.05）. Conclusion There is a significant difference in the levels of Chemerin and RBP4 between pregnant women with gestational diabetes mellitus and non-pregnant women with gestational diabetes mellitus in the early and middle stages of pregnancy, suggesting that this factor is associated with the incidence of gestational diabetes mellitus.