济南铁路局职工非酒精性脂肪肝的发病情况及相关的影响因素

Epidemic characteristics and related risk factors of nonalcoholic fatty liver disease among Jinan Railway Bureau employees

目的 :分析济南铁路局职工非酒精性脂肪肝(NAFLD)的发病情况及相关的影响因素。方法 :将2010年在某院进行健康体检的7593例济南铁路局职工作为研究对象。对这7593例受检者进行超声检查,确诊其是否罹患NAFLD。对这些受检者进行甘油三酯(TG)、总胆固醇(TC)及空腹血糖(FBG)检测,并计算其身体质量指数(BMI),然后分析导致其罹患NAFLD的影响因素。结果 :在本研究中,共有2364例受检者(占31.13%)被确诊患有NAFLD。本研究中各年龄段的男性受检者NAFLD的患病率均远高于女性受检者,差异有统计学意义(P<0.001)。本研究中未患NAFLD的受检者、轻度NAFLD患者、中度NAFLD患者、重度NAFLD患者其TG、TC、FBG的水平及BMI相比较,差异均有统计学意义(P<0.05),而且其TG、TC、FBG的水平及BMI具有随着其NAFLD的发生、加重而升高的趋势。将本研究中的受试者根据其是否罹患NAFLD分为NAFLD组和正常组。NAFLD组患者其TG、TC、FBG的水平及BMI均高于对照组受试者(P<0.001)。经非条件logistic回归分析可知,TG、TC、FBG的水平及BMI是本研究中受试者发生NAFLD的主要影响因素。结论 :济南铁路局职工NAFLD的发病率较高。TG、TC、FBG的水平较高及BMI较大是导致济南铁路局职工罹患NAFLD的主要影响因素。

objective To analyses the epidemic characteristics and related risk factors of nonalcoholic fatty liver disease（NAFLD） among Jinan Railway Bureau employees. Methods Select 7593 Jinan Railway Bureau employees accepted physical examination in a hospital in 2010 for research object. Ultrasound examination was accepted by the 7593 participants for confirm if they suffer from NAFLD. Test their TG,TC and FBG, and compute their BMI, then analyses related risk factors of NAFLD. Results In this research, totally 2364 participants were diagnosed as NAFLD （31.13%）. The morbidity rate of male employees is far above that of female employees （P 〈O.001）. The difference of levels of TG,TC,FBG and BMI of the participants without NAFLD, the participants suffer from mild NAFLD, the participants with moderate NAFLD, the participants with severe NAFLD are all have statistical significant （ P 〈 0.05 ） ,and levels of TG,TC,FBG and BMI are increasing with severity aggravating of NAFLD .Separate the participants depend on whether they are suffering for NAFLD, divide the participants to NAFLD group and control group, levels of TG,TC,FBG and BMI of NAFLD group are higher than that in control group （P 〈 0.001 ） . Through the of unconditioned logistic regression analysis we know levels of TG, TC, FBG and BMI of the participants are main risk factors of NAFLD in this research. Conclusion The morbidity of NAFLD in Jinan Railway Bureau employees is high. Levels of TG, TC, FBG are high, and BMI is large are main risk factors of NAFLD.