急性重症胰腺炎继发感染患者血清中IL-6,IL-8和PCT水平变化及意义研究

Significance of changes of serum IL-6,IL-8,and PCT levels in patients with infection secondary to severe acute pancreatitis

目的研究急性重症胰腺炎继发感染患者血清中白介素-6(interleukin-6,IL-6)、IL-8及降钙素(procalcitonin,PCT)含量的变化及意义.方法选取2016-06/2017-06经中医医院暨中医研究院区中医医院暨中医研究院检验科确诊为急性重症胰腺炎继发感染的患者纳入130例,根据是否感染分为未感染组65例和感染组65例,感染组患者依据感染程度分为重度脓毒血症组27例及非重度脓毒血症组38例,记录分析各组患者在不同时间内IL-6、IL-8及PCT含量.结果住院后的1、3、5、10、15 d内感染组患者的IL-6、IL-8及PCT含量较未感染组显著升高(P<0.05),与第1天比较,第5天和第10天两组患者的I L-6、I L-8及PCT含量均显著降低(P<0.05).感染组PCT阳性检出率高于未感染组(P<0.05).PCT第1天较3、5、10、15检出率低(P<0.05);重度脓毒血症27例患者在住院后的第1、3、5、10、15天内IL-6、IL-8及PCT含量较非重度脓毒血症38例患者明显增高(P<0.05).结论急性重症胰腺炎继发感染患者血清中IL-6,IL-8和P C T含量可以有效的反应感染的发生与发展,对病情的诊断具有十分重要的临床价值.

AIM To observe the changes of serum levels of interleukin （IL）-6, IL-8, and calcitonin （PCT） in patients with infection secondary to acute severe acute pancreatitis （SAP） and to analyze their clinical significance. METHODS From June 2016 to June 2017, 130 patients diagnosed with SAP at our hospital were divided into either a non-infection group （65 cases） or an infection group （65 cases） according to whether infection was present. The infection group was further divided into a severe sepsis group （27 cases） and a non-severe sepsis group （38 cases） according to whether there was severe sepsis infection. Serum levels of IL-6, IL-8, and PCT compared in different groups. RESULTS Serum levels of IL-6, IL-8, and PCT at 1, 3, 5, 10, and 15 d were significantly higher in the infection group than in the non-infection group （P 〈 0.05）. Serum levels of IL-6, IL-8, and PCT in both groups were significantly lower at 5 and 10 d than at I d （P 〈 0.05）. The positive rate of PCT in the infection group was higher than that in the noninfection group （P 〈 0.05）. The detection rate of PCT was significantly lower at I d than at 3, 5,10, and 15 d （P 〈 0.05）. Serum levels of IL-6, IL-8, and PCT at 1, 3, 5, 10, and 15 d were significantly higher in the severe sepsis group than in the non-severe sepsis group （P 〈 0.05）. CONCLUSION Serum levels of IL-6, IL-8, and PCT in patients SAP effectively reflect the occurrence and development of secondary infection, which is of great clinical value for the diagnosis of secondary infection.