乌司他丁治疗小儿重症肺炎的临床疗效

Clinical efficacy and its effect of ulinastatin on serum TNF-α,IL-6,IL-8 and IL-10 levels in children with severe pneumonia

目的评价应用乌司他丁治疗小儿重症肺炎的临床疗效以及对患儿血清TNF-α、IL-6、IL-8、IL-10水平的影响。方法选择我院就诊的76例重症肺炎患儿,随机分为对照组(38例)和实验组(38例),对照组给予抗感染和对症支持治疗,实验组在对照组的基础上联合乌司他丁,比较两组患儿的临床疗效。结果实验组的治疗总有效率显著高于对照组(94.74%vs 78.95%,P<0.05)。治疗后,实验组患儿发热、紫绀、呼吸困难、胸腔积液和ICU留住时间明显低于对照组(P<0.05)。两组患儿治疗后SP-A和SP-D水平较治疗前有明显下降,其中实验组的降幅最为显著(P<0.05)。实验组治疗后TNF-α、IL-6和IL-8水平明显低于对照组,IL-10明显高于对照组,差异间具有统计学意义(P<0.05)。结论在小儿重症肺炎中应用乌司他丁治疗具有的较高临床疗效,并可以有效调节患儿血清TNF-α、IL-6、IL-8、IL-10水平。

Objective To observe the clinical efficacy and its effect of ulinastatin on serum TNF-α,IL-6,IL-8 and IL-10 levels in children with severe pneumonia. Methods From January 2015 to June 2017,76 children with severe pneumonia were randomly divided into the control group and the experimental group（ 38 cases in each group）. All of them were given conventional treatment,and the experimental group was combined with ulinastatin,respectively. The clinical efficacy was comparatively analyzed. Results The total effective rate of the treatment group was significantly higher than that of the control group（ 94. 74% vs. 78. 95%,P〈0. 05）. The duration of fever,cyanosis,dyspnea,pleural effusion and ICU retention in the experimental group was significantly lower than that in the control group（ P〈0. 05）. The levels of SP-A and SP-D in the two groups were obviously lower,while compared with those before treatment,and the improvement in the experimental group was more pronounced（ P〈0. 05）.The levels of TNF-α,IL-6 and IL-8 in the experimental group were significantly lower,and the level of IL-10 was significantly higher than that in the control group（ P〈0. 05）. Conclusion Ulinastatin has a higher clinical efficacy in treatment of children with severe pneumonia,which can effectively regulate the serum levels of TNF-α,IL-6,IL-8 and IL-10 in children.