炎性细胞因子IL-8对慢性鼻-鼻窦炎伴鼻息肉患者术后复发的预测价值初步探讨

The predictive value of inflammatory cytokines IL-8 for recurrence of chronic rhinosinusitis with nasal polyps

目的炎性细胞因子IL-8对于慢性鼻-鼻窦炎伴鼻息肉患者出现复发的临床预测价值研究。方法从2014年10月至2016年10月在就诊于我院的慢性鼻-鼻窦炎伴鼻息肉患者资料进行分析。主要根据患者治疗前血清IL-8水平将患者具体分为血清IL-8正常组40例、血清IL-8增高组40例。对比两组患者在进行相同手术治疗后的视觉模拟量表评分、嗅觉功能评分以及复发率。结果两组患者治疗后在视觉模拟量表评分、嗅觉功能评分上差异并无统计学意义;复发率在正常组和增高组中分别为10%和30%;增高组患者的复发率要明显高于正常组(P<0.05)。结论慢性鼻-鼻窦炎伴鼻息肉患者治疗前血清炎性细胞因子IL-8的高含量将会直接影响患者手术后的复发率,在临床具有一定的预测意义。

Objective To explore the predictive value of inflammatory cytokines IL-8 for recurrence of chronic rhinosinusitis with nasal polyps. Methods From October 2014 to October 2016, the data of patients with chronic rhinosinusitis and nasal polyps were analyzed. According to the level of serum IL-8 before treatment, patients were divided into 40 cases of normal group, and 40 cases of elevated group. The scores of visual analogue scale, olfactory function and recurrence rate of the two groups were compared between the two groups after the same operation. Results There was no significant difference between the two groups in the visual analogue scale score and olfactory function score after treatment. The recurrence rate was 10% and 30% respectively in the normal group and elevated group. The recurrence rate of elevated group was significantly higher than that of the normal group（P〈0.05）. Conclusion The high level of serum inflammatory cytokines IL-8 before treatment would directly affect the recurrence rate of chronic rhinosinusitis patients with nasal polyps, which has some predictive value in clinic.