硝苯地平、酚妥拉明及硫酸镁三药联用对妊娠期高血压疾病患者血清CysC含量的影响

Effects of nifedipine,phentolamine and magnesium sulfate on serum CysC levels in patients with pregnancy-induced hypertension

目的观察硝苯地平、硫酸镁及酚妥拉明三药联用对妊娠期高血压疾病患者血清胱抑素C(cystatin C,CysC)含量的影响,并探讨其治疗妊娠期高血压疾病的价值。方法选取妊娠期高血压疾病患者318例,根据自愿参与原则,采用随机数字表法分为研究组、对照组1、对照组2各106例。其中研究组给予硝苯地平、硫酸镁及酚妥拉明三药联合治疗,对照组1给予硝苯地平和硫酸镁治疗,对照组2给予酚妥拉明和硫酸镁治疗,分析研究组与对照组1和对照组2治疗前后血清CysC含量的变化。结果治疗前3组血清CysC含量差异无统计学意义(P>0.05);治疗后3组血清CysC含量均低于治疗前,研究组血清CysC含量低于对照组1和对照组2(P<0.05),对照组1与对照组2血清CysC含量差异无统计学意义(P>0.05)。结论硝苯地平、硫酸镁及酚妥拉明三药联用治疗妊娠期高血压疾病患者,其降低血清CysC含量的的效果明显优于其他两药联用,说明对妊娠期高血压疾病患者具有理想的治疗价值。

Objective To observe the influence of nifedipine,magnesium sulfate and phentolamine on the level of cystatin C（CysC）in the patients with pregnancy-induced hypertension（PIH）,and to explore the therapeutic value of the combination of the three drugs for the treatment of PIH.Methods Three hundred and eighteen PIH patients were selected in this study,according to the rule of voluntary participation.Among them,106 patients were selected into the study group,and the rest were selected into control group 1 and control group 2 with 106 patients in each group.The selection was based on the random number table method.The study group was given the three-drug therapy of nifedipine,magnesium sulfate and phentolamine.The control group 1 was given nifedipine and magnesium sulfate treatment while control group 2 received phentolamine and magnesium sulfate treatment.The serum CysC levels before and after the treatment for these three groups were measured and compared.Results Before treatment,there was no statistical difference of the serum CysC level in these three groups（P〉0.05）.After treatment,the serum CysC level was decreased in all groups.In the study group,the serum CysC level was significantly lower than that in the two control groups（P〈0.05）.There was no statistically significant difference between control group 1 and control group 2（P〉0.05）after treatment.Conclusion The three-drug therapy combined bynifedipine,magnesium sulfate and phentolamine was shown to be reliable and more successful than the two-drug therapies in reducing the serum CysC level in the patients with PIH.The paper indicates that the three-drug therapy is effective in treating patients with PIH.