苯甲酰咪唑过氧化反应

Peroxidation of Benzoylimidazole

以苯甲酰咪唑和叔丁基过氧化氢为反应物,1,8-二氮杂二环十一碳-7-烯(DBU)为催化剂,乙睛(CH_3CN)作为反应溶剂,合成了过氧化叔丁酯类化合物。分别考察了不同催化剂及其用量、原料配比、溶剂、温度和时间对反应的影响,在最优条件下,共得到25个目标产物,收率范围为45%~99%。目标化合物经核磁共振氢谱、核磁共振碳谱以及质谱进行了结构表征。该方法具有操作简单、反应条件简单温和、产物收率高及底物适用性好等优点,为过氧化叔丁酯类化合物的合成提供了新的思路。

In this paper,the experimental methods for the synthesis of t-butyl peroxide compounds were discussed,in which benzoyl imidazole and t-butyl hydroperoxide（ TBHP） were used as reactants,1,8-diazabicycloundec-7-ene（ DBU） was used as the catalyst and acetonitrile（ CH3 CN） was used as the reaction solvent. The effect of catalysts and their dosage,raw material ratios,solvents and temperature on the yield were investigated. A total of 25 target products were obtained under the optimum conditions with yields of45% ~ 99%. The molecular structures of the products were analyzed by nuclear magnetic resonance spectroscopy（1 H NMR and13 C NMR） and mass spectrometry. The method has the advantage of easily available material,easy operation,mild reaction conditions and a wide range of functional group tolerance,and has provided a new idea for the synthesis of t-butyl peroxide compounds.