甲基丙烯酸二乙氨基乙酯的合成工艺改进

Improvement of Synthesis Process of 2-Diethylaminoethyl Methacrylate

对以甲基丙烯酸甲酯和二乙氨基乙醇为原料,氢氧化锂为催化剂,通过酯交换合成甲基丙烯酸二乙氨基乙酯的改进工艺进行了研究。该工艺以正己烷为携甲醇溶剂,采用分水器从反应体系中不断地分出甲醇。得到较佳反应条件:n(甲基丙烯酸甲酯)∶n(二乙氨基乙醇)∶n(催化剂)=2.4∶1∶0.42,反应时间为6h,反应温度约70℃。在以上条件下,目标产物的含量为94.96%,收率为93.16%。该工艺具有反应条件温和、催化剂廉价易得、产品含量及收率高、设备简单等优点。

2-Diethylaminoethyl methacrylate was synthsezied through improved transesterification process by using diethylaminoethanol（DEA）and methyl methacrylate（MMA）as raw materials,LiOH as catalyst where methanol was continuously separated from the reaction system with water separator and n-hexane as a methanol-carring agent.The results revealed that the optimum reaction conditions were as follows：n（MMA）∶n（DEA）∶n（LiOH）=2.4∶1∶0.42,reaction time being 6 h,and reation temperature being about 70 ℃.Under the above conditions,the yield of the products could be up to 93%,the purity was close to95%.The process has some advantages such as mild reaction condition,cheap catalyst,high yield and purity as well as simple equipment.