辛伐他汀对脑动脉粥样硬化患者炎性因子和血脂的影响

Effect of simvastatin on inflammatory factors and blood lipid in patients with cerebral atherosclerosis

目的研究辛伐他汀对脑动脉粥样硬化患者炎性因子和血脂的影响。方法将我院收治的200例脑动脉粥样硬化患者根据治疗方法分为A组和B组,各100例。A组行常规治疗,B组在A组基础上运用辛伐他汀。比较两组的治疗效果。结果治疗后,两组患者的CRP、IL-6、IL-18、HDL-C、TC、LDL-C及TG水平明显优于治疗前,且B组明显优于A组(P<0.05)。结论对脑动脉粥样硬化患者采取辛伐他汀进行治疗,不仅可以降低炎性因子水平,还能改善患者的血脂水平,有利于进一步提高治疗效果。

Objective To study the effect of simvastatin on inflammatory fastors and blood lipid in patients with cerebral atheroselerosis. Methods＇ Two hundred patients with cerebral atheroselerosis admitted in our hospital were divided into group A and group B according to treatment methods, with 100 cases in each group. Group A was treated with routine treatment, and the group B was given simvastatin on the basis of group A. The effects between the two groups were com- pared. Results After treatment, the levels of CLIP, IL-6, IL-18, HDL-C, TC, LDL-C and TG of the two groups were better than those before treatment, and those of the group B were better than the group A （P〈0.05）. Conclusion Simvastatin in the treatment of cerebral atheroselerosis can not only reduce the level of inflammatory factors, but also improve the blood lipid level of the patients, which is beneficial to further improve the therapeutic effect.