帕罗西汀联合无抽搐电休克治疗对难治性抑郁症的临床效果及认知功能的影响

Effect of paroxetine combined with non-convulsive electrical shock treatment in refractory depression and its influence on cognitive function

目的观察帕罗西汀联合无抽搐电休克治疗难治性抑郁症的临床效果。方法将86例难治性抑郁症患者随机分为对照组和观察组,每组43例。对照组采用帕罗西汀治疗,观察组在对照组的基础上加用无抽搐电休克治疗。比较两组的治疗效果、治疗前、后的抑郁情况及记忆、认知功能情况。结果观察组患者的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组患者的HAMD评分显著低于治疗前,且观察组显著低于对照组(P<0.05)。治疗后,观察组患者的WMS、MMSE评分均高于治疗前与对照组(P<0.05)。结论采用帕罗西汀联合无抽搐电休克治疗难治性抑郁症临床效果显著,值得临床推广应用。

Objective To observe the clinical effect of paroxetine combined with non-convulsive electrical shock treatment in refractory depression. Methods＇ Eighty-six patients with refractory depression were randomly divided into control group and observation group, with 43 cases in each group. The control group was treated with paroxetine, while the observation group was treated with non-convulsive electrical shock on the basis of the control group. Therapeutic effects, depression, memory and cognitive function before and afler treatment in the two groups were observed. Results The total effective rate of the observation group was significantly higher than that of the control group （P〈0.05）. After treatment, the HAMD scores of both groups significantly decreased, and that in the observation group was significantly lower than the control group （P〈0.05）. After treatment, the WMS and MMSE scores in the observation group were higher than those before treatment and the control group （P〈0.05）. Conclusion Paroxetine combined with non-convulsive electrical shock treatment in refractory depression has a significant clinical effect, which is worthy of clinical application.