腹腔镜下根治性手术治疗肾癌患者对血清Ang、VEGF及T细胞亚群的影响

Influence of laparoscopic radical operation on serum Ang, VEGF and T cell subsets in patients with renal carcinoma

目的分析腹腔镜下根治性手术治疗肾癌患者对血清血管生成素(Ang)、血管内皮生长因子(VEGF)及T细胞亚群的影响。方法选取120例肾癌患者随机分为对照组(60例,给予开式手术)与研究组(60例,给予腹腔镜手术)。对比术前、术后3d两组血清Ang、VEGF、T细胞亚群水平等指标变化情况。结果术后3 d,研究组Ang-1、Ang-2、ATIR、VEGF-A、VEGF-C、VEGF-D显著低于对照组(P<0.05);两组CD3^+、CD4^+、CD4^+/CD8^+均显著降低,但研究组显著高于对照组(P<0.05)。结论腹腔镜下根治性手术对肾癌患者血清Ang、VEGF及T细胞亚群的影响更小。

Objective To analyze the influence of laparoscopic radical operation on serum angiogenin （Ang）, vascular endothelial growth factor （VEGF） and T lymphocyte subsets in patients with renal carcinoma. Methods＇ A total of 120 patients with renal cancer were randomly divided into control group （60 cases, given open surgery） and study group （60 cases, given laparoseopie radical surgery）. The levels of serum Ang, VEGF and T cell subsets in the two groups were compared before operation and at 3 d after operation. Results＇ The levels of Ang-1, Ang-2, ATIR and VEGF-A, VEGF-C and VEGF-D at postoperative 3 d in the study group were significantly lower than those in the control group （P〈0.05）. The levels of CD3＋, CD4＋ and CD4＋/CD8＋ in the two groups decreased significantly after operation, and those of the study group were significantly higher than the control group （P〈0.05）. Conclusion Laparoseopie radical surgery has less effect on serum Ang, VEGF and T cell subsets in patients with renal carcinoma.