不同雾化吸入疗法治疗小儿支气管哮喘的疗效对比

Effects comparison of different inhalation therapy in children with bronchial asthma

目的对比不同雾化吸入疗法治疗小儿支气管哮喘的临床效果。方法将我院收治的144例支气管哮喘患儿随机分为参照组(沙丁胺醇雾化吸入治疗)与研究组(沙丁胺醇+布地奈德雾化吸入治疗),各72例。比较两组患儿的临床效果。结果治疗后,两组患儿Ig E、IL-4、IL-13水平均降低,且研究组低于参照组(P<0.05);与参照组比较,研究组ACT评分及总有效率明显更高(P<0.05)。结论相比仅使用沙丁胺醇雾化吸入治疗,沙丁胺醇联合布地奈德雾化吸入治疗应用于支气管哮喘患儿的临床治疗可显著降低血清炎性因子水平,增强机体抵抗力,改善哮喘情况,有广泛临床应用价值。

Objective To compare the efficacy of different inhalation therapy in children with bronchial asthma. Meth- ods＇ A total of 144 children with bronchial asthma admitted in our hospital were randomly divided into reference group （72 cases, salbutamol inhalation therapy） and study group （72 cases, salbutamol＋budesonide inhalation therapy）. The clinical effects were compared between the two groups. Results After treatment, the levels of IL-4, IL-13 and IgE in the two groups decreased, and those of the study group were lower than the reference group （P〈0.05）. Compared with the reference group, there were higher ACT scores and total effective rate in the study group （P〈0.05）. Conclusion Compared with using salbu- tamol inhalation alone, the combination of budesonide and budesonide inhalation in children with bronchial asthma can sig- nificantly reduce serum levels of inflammatory cytokines, enhance the body＇s resistance and improve asthma control and therapeutic effect, which has wide clinical application value.