甲状腺功能正常的抑郁症患者不同促甲状腺素水平时抑郁情况比较

Comparative study of depression severity at different thyrotropin levels in depressive patients with normal thyroid function

目的针对甲状腺功能正常的抑郁症患者,比较不同促甲状腺素(TSH)水平时患者的抑郁情况,探索正常甲状腺功能对抑郁症的影响。方法选取在天津市精神卫生中心住院治疗的甲状腺功能正常的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的抑郁症患者77人,根据TSH水平是否大于中位数,将患者分为TSH低值组(n=51)和高值组(n=26)。采用汉密尔顿抑郁量表17项版(HAMD-17)评定患者抑郁情况,比较两组的抑郁状态。结果 TSH低值组自杀、胃肠道症状和疑病项目评分均高于TSH高值组,差异均有统计学意义(t=-1.11、2.42、2.32,P均<0.05)。结论甲状腺功能正常的抑郁症患者,TSH水平越低,抑郁情绪越明显。

Objective For depressive patients with normal thyroid function,the depression situations of patients with different thyrotropin（ TSH） levels were compared which help to explore the influence of normal thyroid function on depression. Methods A total of 77 depression patients who met the criteria of the International Classification of Diseases,tenth edition（ ICD-10） with normal thyroid function from Tianjin Mental Health Center were selected. They were divided into low TSH and high TSH groups based on their TSH levels. Hamilton Depression Scale 17-item（ HAMD-17） was used to assess the depression situation of all patients,and the depression status was compared between the two groups. Results The scores on suicidal, gastro-intestinal symptoms and hypochondriasis were higher than those of the high TSH group（ t =-1. 11,2. 42,2. 32,P〈0. 05）. Conclusion For depression patients with normal thyroid function,the lower the TSH level,the depression severer.