血管性认知障碍患者血清中NSE、GFAP、BDNF水平变化的研究

Changes of Serum Levels of NSE,GFAP and BDNF in Patients with Vascular Cognitive Impairment

目的探讨血管性认知障碍患者血清神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、脑源性神经营养因子(BDNF)水平变化与认知障碍严重程度的相关性。方法选择血管性认知障碍患者150例,入院时均给予相应治疗,并进行NSE、GFAP、BDNF检测。将150例患者依据认知障碍程度分为轻度认知障碍组(69例)、中度认知障碍组(45例)和重度认知障碍组(36例)。并比较不同损伤水平(MMSE评分)患者3个指标之间的差异、计算3个指标与MMSE的相关性。结果轻度患者组、中度患者组以及重度患者组间血清BDNF、NSE、GFAP水平存在显著差异,具有统计学意义(P<0.01)。血清NSE、GFAP水平与MMSE呈负相关(r=-0.641,r=-0.604,P<0.05),BDNF与MMSE评分呈正相关(r=0.582,P<0.05)。结论认知功能障碍的严重程度与血管性认知障碍患者血清NSE、GFAP、BDNF水平密切相关,因此血管性认知障碍患者血清NSE、GFAP、BDNF水平可用于判断认知功能障碍的严重程度。

Objective To investigate the change of the serum neuron specific enolase（ NSE）,glial fibrillary acidic protein（ GFAP）,and brain derived neural nutrition factor（ BDNF） in cognitive impairment patients and their correlations with vascular cognitive impairment. Methods We selected 150 cases of cognitive impairment patients for this research. The patients were given corresponding treatments in our hospital,and the levels of NSE,GFAP and BDNF of patients were detected. According to the cognitive impairment levels,all of these patients were divided into 3 groups： 69 in mild cognitive impairment group,45 in moderate cognitive impairment group and 36 in severe cognitive impairment group. Those three indicators were compared between different levels of cognitive injury（ MMSE score） groups,and we also investigated the correlation between the three indicators and MMSE levels. Results The levels of NSE,GFAP and BDNF were significantly different cross the mild subgroup,moderate subgroup and severe subgroup（ P〈0. 01）. The levels of NSE and GFAP were negatively correlated with MMSE scores（ r =-0. 641,r =-0. 604,P〈0. 05）,and BDNF was positively correlated with MMSE scores（ r = 0. 582,P〈0. 05）. Conclusion The levels of NSE,GFAP and BDNF in cognitive impairment patients are closely related with the severity of cognitive function,which can be used to determine the severity of cognitive impairment in vascular cognitive impairment patients.