骨髓转移瘤373例组织形态学特点

Bone marrow metastatic tumour: clinicopathological features of 373 cases

目的回顾性分析骨髓转移瘤的组织形态学特点。方法选取本科室2012-01—2017-07间54425例病理档案中373例(0.69%)骨髓转移瘤患者的临床病理学资料进行回顾性分析。结果 373例骨髓转移瘤中,腺癌343例(91.9%),鳞状细胞癌3例(0.8%),小细胞癌19例(5.1%),血管肉瘤2例(0.5%),胃肠间质瘤1例(0.3%),神经母细胞瘤3例(0.8%),胶质瘤1例(0.3%),分类不明肉瘤1例(0.3%)。结论骨髓活检在诊断骨髓转移性肿瘤及追溯原发部位和实体瘤的分期中,具有不可替代的作用。成年男性常见的骨髓转移瘤为前列腺癌、胃肠道癌、小细胞癌等,女性常见的骨髓转移瘤是乳腺癌及胃肠道癌等。

Objective To investigate the clinicopathological features of bone marrow metastatic tumours. Mehods A total of 373 cases of bone marrow mastatic tumours among 54425 cases of bone marrow biopsy from January 2012 to July2017 were analyzed. Results Among the 373 cases,343 cases were adenocarcinoma,accounting for 91. 96%; 3 case were squamous cell carcinoma,accounting for 0. 80%; 19 cases were small cell carcimoma,accounting for 5. 09%; 2 case were hemangiosarcoma,accounting for 0. 54%; 1 case were gastrointestinal stomal tumour,accounting for 0. 27%; 3 cases were neuroblastoma,accounting for 0. 80%; 1 case were glioma, accounting for 0. 27%; 1 case were sarcoma,unclassifiable,accounting for 0. 27%. Conclusion Bone marrow biopsy is very useful for the diagnosis of bone marrow metastatic tumours and assessment of stage. The highest number of bone marrow metastic tumours is seen in carcinoma of the prostate,followed by carcinoma of gastrointestinal tract and small cell carcinoma in male patients; adenocarcinoma of the breast followed by carcimomas of gastrointestinal tract in female patients.