摘要
烟碱型乙酰胆碱受体(nAChR)是离子通道型受体,属于Cys-loop受体的超级家族,通过配体门控离子通道介导许多生理活动,是治疗精神类疾病的重要靶点。nAChR包括肌肉型和神经型2种。nAChR是由5个亚基组成的具有中心孔道的五聚体,本文简要介绍了近年来烟碱乙酰胆碱受体结构的研究进展。
Nicotinic acetylcholine receptor（nAChR）belongs to the Cys-loop receptor family of ligandgated ion channels mediating many physiological activities in the nervous system,and is an important drug target for treatment of neurological diseases.It contains both the muscle-type nAchR and the neuron-type nAchR.nAChR is a pentamer consisting of five subunits with a central channel.The recent advances of the structure of nicotinic acetylcholine receptor have been introduced in this article.
作者
马倩芸
江涛
于日磊
MA Qian-yun;JIANG Tao;YU Ri-lei(Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, Chin)
出处
《中国海洋药物》
CAS
CSCD
2018年第2期97-102,共6页
Chinese Journal of Marine Drugs
基金
国家自然科学基金青年科学基金项目(81502977)
国家博士后特助项目(2016T90655)资助
关键词
烟碱乙酰胆碱受体
离子通道受体
五聚体
nicotinic acetylcholine receptor
ligand-gated ion channels
pentamer
