左乙拉西坦与丙戊酸钠治疗伴中央颞区棘波儿童良性癫痫的疗效

Efficacy of levetiracetam and valproate in treating children with benign childhood epilepsy with centrotemporal spikes

目的比较左乙拉西坦(LEV)与丙戊酸钠(VPA)治疗伴中央颞区棘波儿童良性癫痫(BECT)的临床疗效。方法选取BECT患儿36例,分为LEV组和VPA组,每组18例,治疗12个月。比较两组临床疗效。结果治疗12个月后,两组总有效率差异无统计学意义(P>0.05)。LEV组脑电图痫样放电较VPA组减少(P<0.05);LEV组言语智商和总智商得分高于VPA组(P<0.05)。结论 LEV及VPA治疗BECT临床疗效相当;但LEV对患儿的脑电图痫样放电和认知水平改善效果更好。

Objective To compare the clinical efficacy of levetiracetam （LEV） and valproate （VPA） in the treatment of children with benign childhood epilepsy with centrotemporal spikes （BECT）. Methods The BECT in 36 children was treated with LEV（group LEV, 18 cases） or VPA （group VPA, 18 cases） for 12 months. The clinical efficacy was compared between two groups. Results After treated for 12 months, the overall effectiveness rate of groups of LEV and VPA was similar （94. 4 % vs. 88. 9 %）（P〉0. 05）. Compared to group VPA, the decrease of EEG epilepsy-like discharge was more and the scores of verbal intelligence quotient and total intelligence quotient were higher in group VPA （P〈0. 05）. Conclusion Both of LEV and VPA have similar clinical efficacy in the treatment of children with BECT. Compared to VPA, LEV is more effective in reducing EEG epilepsylike discharge and improving cognitive function.