疏肝健脾调脂颗粒治疗冠心病介入术后抑郁障碍的临床研究

Clinical Effects of the Shuganjianpitiaozhi Granule on Depressive Disorder Following Coronary Intervention Surgery

目的:观察疏肝健脾调脂颗粒治疗冠心病介入术(PCI)后抑郁障碍的临床疗效。方法:将冠心病PCI后出现抑郁障碍的60例患者随机分成对照组和治疗组,每组30例。两组均给予扩冠、抗凝、调脂、抗血小板聚集等常规治疗,对照组在此基础上应用心理干预治疗,治疗组基于对照组加用疏肝健脾调脂颗粒。治疗12周后,观察两组患者血脂[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]及汉密尔顿焦虑量表(HAMA)、抑郁量表(HRSD)评分的变化。结果:治疗后,患者临床症状改善程度治疗组较对照组更为明显(P<0.05);治疗组在调节血脂作用方面(降低TC及LDL-C水平)优于对照组,差异有统计学意义(P<0.05);在改善患者抑郁障碍上,治疗组的HAMA、HRSD评分均低于对照组,差异有统计学意义(P<0.05)。结论 :PCI术后抑郁障碍者联合应用疏肝健脾调脂颗粒治疗,可显著改善患者焦虑、抑郁等临床症状,且调节血脂更优。

Objective： To observe Shuganjianpit iaozhi granule in treatment of depressive disorder following coronary intervention surgery effect. Methods： 60 Cases of depressive disorder following coronary intervention surgery were randomly divided into treatment group（30 cases） and control group（30 cases）, the control group adopted conventional treatment and psychological intervention, the treatment group accepted Shuganjianpitiaozhi granule on the basis of the control group. Level of total cholesterol, Hamilton anxiety Scale（HAMA）, Hamilton Depression Rating Scale for depression（HRSD） were measured before and after treatment. Results： After treatment,HAMA and HRSD scores, the levels of TC, TG, LDL-C, and clinical symptoms of the two groups were significantly better than those before treatment, and the treatment group better than the control group（P0.05）. Conclusion： Shuganjianpitiaozhi granule combined with conventional treatment in treatment of depressive disorder following coronary intervention surgery, can significantly improve clinical symptoms and blood lipids.