抑制素A预测胎膜早破的相关研究

Study on the prediction of premature rupture of membranes with inhibin A

目的 探讨孕妇血清抑制素A水平与胎膜早破的关系。方法 选取单胎孕龄36~37＋6周孕妇32例，其中发生胎膜早破18例（胎膜早破组），未发生胎膜早破14例（非胎膜早破组）。采用酶联免疫吸附法检测两组孕妇血清抑制素A水平。结果 胎膜早破组血清抑制素A水平明显高于非胎膜早破组（1 253.5 ng/L比698.1 ng/L），差异有统计学意义（P〈0.05）。受试者工作特征曲线分析结果显示，血清抑制素A预测胎膜早破的最佳截断值为984.45 ng/L，敏感度为72.2%，特异度为78.6%，曲线下面积为0.77，95% CI 0.59~0.95。结论 血清抑制素A水平对胎膜早破有一定的预测价值。

Objective To explore the relationship between the level of the pregnant women serum inhibin A and premature rupture of membranes.Methods Thirty-two pregnant women with the gestational age 36-37＋6 weeks were selected, including 18 cases with premature rupture of membranes （premature rupture of membranes group） and 14 cases without premature rupture of membranes （none premature rupture of membranes group）. The serum level of inhibin A was measured by enzyme-linked immunosorbent assay method.Results The serum level of inhibin A in premature rupture of membranes group was significantly higher than that in none premature rupture of membranes group （1 253.5 ng/L vs. 698.1 ng/L）, and there was statistical difference （P〈0.05）. The receiver-operating characteristic curve analysis result showed that the optimal cut-off value of serum level of inhibin A to predict premature rupture of membranes was 984.45 ng/L, with a sensitivity of 72.2% and a specificity of 78.6%, and the area under the curve was 0.77 （95% CI 0.59-0.95）.Conclusions The serum level of inhibin A has a certain predictive value for premature rupture of membranes.