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新生儿坏死性小肠结肠炎早期诊断生物标记物的研究进展 被引量:9

Early diagnosis biomarkers of neonatal necrotizing enterocolitis
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摘要 坏死性小肠结肠炎(necrotizing enterocolitis of newborn,NEC)是早产儿常见的严重消化道疾病,起病急,死亡风险高,早期临床症状常不典型,放射学检查缺乏敏感性,故仅通过临床表现及影像学结果来早期诊断有时不可靠。近来发现,某些生物标记物,如肠脂肪酸结合蛋白、肠三叶因子、β-葡萄糖苷酶、粪钙卫蛋白等,在NEC发病早期有一定的变化,对指导NEC临床治疗和评估病情有一定的指导作用。 Necrotizing enterocolitis(NEC) is a serious disease of digestive tract common in premature infants, which is acute onset with high risk of death. Its early clinical symptoms are not typical, and it lacks sensitivity in radiological examination, so it is sometimes unreliable only based on the clinical manifes- tation and imaging results for early diagnosis. Recently, some biomarkers have certain changes in the early onset of NEC, such as intestinal fatty acid binding protein, intestinal trefoil factor, β-glucosidase, fecal calprotectin, which have certain significance to guide the clinical treatment and evaluate the severity of NEC.
作者 陈仁慧(综述) 富建华(审校) Chen Renhui;Fu Jianhua.(Department of Neonatology , Shengjing Hospital, China Medical University, Shenyang 110004, China)
出处 《中国小儿急救医学》 CAS 2018年第4期301-305,共5页 Chinese Pediatric Emergency Medicine
关键词 生物标志物 坏死性小肠结肠炎 新生儿 Biomarker Necrotizing enterocolitis Neonate
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  • 1Neu J,Walker WA. Necrotizing enterocolitis. N Engl J Med, 2011,364(3) : 255-264.
  • 2Funaoka H,Kanda T,Kajiura S, et al. Development of a high- specificity sandwich ELISA system for the quantification of human intestinal fatty acid-binding protein (I-FABP) concentra- tions. Immunological Investigations, 2011,40 (3) : 223-242.
  • 3Pelsers MM, Hermens WT,Glatz JFC. Fatty acid-binding pro- teins as plasma markers of tissue injury. Clin Chim Acta, 2005, 352(1-2) : 15-35.
  • 4Walsh MC,Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am, 1986,33 (1) : 179-201.
  • 5Coursey CA, Hollingsworth CL, Gaca AM, et al. Radiologists" agreement when using a 10 point scale to report abdominal radiographic findings of necrotizing enterocolitis in neonates and infants. AJR, 2008,191( 1 ) : 190-197.
  • 6Najaf TA, Vachharajani NA, Warner BW, et al . Interval between clinical presentation of necrotizing enteroeolitis and bow el perforation in neonates. Pediatr Surg Int, 2010 , 26 (6) : 607- 609.
  • 7Srinivasiois R, Nathan E, Doherty D, et al. Prediction of pro- gression of definite necrotising enterocolitis to need for surgery or death in preterm neonates. Matern Fetal Neonatal Med, 2010 ,23(7):695-700.
  • 8Parikh M, Samujh R, Kanojia RP, et al. Decision-making in sur- gical neonatal necrotizing enteroeolitis. Indian Assoc Pediatr Surg,2009,14(3) : 102-107.
  • 9Ververidis M, Kiely EM, Spitz L, et al. The clinical significance of throm bocytopenia in neonates with necrotizing enterocolitis. J Pediatr Surg, 2001,36 (5): 799-803.
  • 10Pourcyrous M, Korones SB, Yang W, et al. C-reactive protein in the diagnosis,management, and prognosis of neonatal necrotiz ing enteroeolitis. Pediatrics, 2005,116 (5) : 1064-1069.

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