氧化石墨烯在骨组织工程中的研究进展

Recent advances in application of graphene oxide for bone tissue engineering

目的对近年来氧化石墨烯(graphene oxide,GO)纳米材料在骨组织工程领域的研究进展作一综述。方法广泛查阅近年来有关GO用于骨缺损再生修复研究的国内外文献,对GO一般性质、降解性能、生物相容性以及在骨组织工程中的应用进行综述。结果 GO具有表面带有大量含氧基团、比表面积高、生物相容性好,能促进干细胞黏附、增殖和分化等特点,在构建新型复合支架、改善传统支架性能等方面具有较多优势。结论GO因具有理想的理化性质已成为骨组织工程领域研究热点,但仍存在许多问题需要进一步研究明确。

Objective To review the recent advances in the application of graphene oxide（GO） for bone tissue engineering. Methods The latest literature at home and abroad on the GO used in the bone regeneration and repair was reviewed, including general properties of GO, degradation performance, biocompatibility, and application in bone tissue engineering. Results GO has an abundance of oxygen-containing functionalities, high surface area, and good biocompatibility. In addition, it can promote stem cell adhesion, proliferation, and differentiation. Moreover, GO has many advantages in the construction of new composite scaffolds and improvement of the performance of traditional scaffolds. Conclusion GO has been a hot topic in the field of bone tissue engineering due to its excellent physical and chemical properties. And many problems still need to be solved.