幽门螺旋杆菌感染与颈动脉内膜中层厚度相关性的Meta分析

Relationship Between Helicobacter Pylori Infection and Carotid Intima Thickness by Meta–analysis

目的:探讨幽门螺旋杆菌感染和颈动脉内膜中层厚度之间的关系。方法:计算机检索Pubmed、Embase、CNKI、维普及万方数据库,搜集国内外已经公开发表的关于幽门螺旋杆菌感染与颈动脉内膜中层厚度相关性的研究。由2位评价员筛选并纳入相关文献,提取文献特征并根据Jadad量表评价纳入文献的质量。利用Stata12.0软件对其进行综合分析。结果:经检索和筛选,共纳入9项病例对照研究,文献质量评分均≥4分,共有694例幽门螺旋杆菌阳性者和676例幽门螺旋杆菌阴性者。Meta分析显示,幽门螺旋杆菌阳性者的颈动脉内膜中层厚度高于幽门螺旋杆菌阴性者[标准化均数差值(SMD)=0.803,95%可信区间(CI):0.686~0.919,P<0.05]。亚组分析显示,在≥60岁和<60岁的患者中,幽门螺旋杆菌感染阳性者的颈动脉内膜中层厚度均高于幽门螺旋杆菌阴性者(≥60岁:SMD=1.296,95%CI:1.125~1.467,P<0.05;<60岁:SMD=0.379,95%CI:0.220~0.537,P<0.05)。结论:幽门螺旋杆菌感染与颈动脉内膜中层厚度有关,可以使颈动脉内膜增厚。

Objectives： To investigate the relationship between helicobacter pylori（Hp） infection and carotid intima thickness.Methods： We searched the databases of Pubmed, Embase, CNKI, VIP and Wanfang for published studies on the relationship between Hp infection and carotid intima thickness in China and abroad. 2 reviewers independently identified and enrolled the articles, extracted specific data and assessed the quality of reference by Jadad scale. Meta-analysis was conducted by Stata 12.0 Software.Results： A total of 9 case-control studies were enrolled, all the reference quality scores≥4 which included 694 subjects with Hp positive and 676 with Hp negative. Meta-analysis indicated that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects, standard mean difference（SMD）=0.803, 95% CI（0.686-0.919）, P 0.05. Age related study presented that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects at the age≥60 years＇ population, SMD=1.296, 95%CI（1.125-1.467）, P〈0.05; carotid intima thickness was also higher in Hp positive subjects than Hp negative subjects at the age60 years＇ population, SMD=0.379, 95%CI（0.220-0.537）, P〈0.05.Conclusions： Hp infection has been related to the thickness of carotid intima and it could make carotid artery intima thickening.