中药保留灌肠对急性出血性放射性肠炎的疗效及护理观察

Clinical Efficacy and Nursing Experience of Retention Enema with Chinese Herbal Medicine on Acute Hemorrhagic Radiation Enteritis

目的观察中药保留灌肠对急性出血性放射性肠炎患者的氧化应激指标和凝血功能的影响及护理体会。方法 64例急性出血性放射性肠炎患者,随机分为对照组与治疗组各32例,对照组给予复方谷氨酰胺肠溶胶囊治疗,治疗组在对照组的基础上给予中药保留灌肠的护理方法。比较两组患者治疗前后生存质量(SF-36)、氧化应激指标[一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]、凝血功能[血红蛋白(HGB)、纤维蛋白原(FIB)、凝血酶原时间(PT)、血小板(PLT)]的变化和出血停止时间,并评价两组患者的临床疗效。结果对照组总有效率为84.38%,治疗组总有效率为96.88%,治疗组明显优于对照组(P<0.01);治疗组治疗后情绪功能、躯体功能、角色功能、认知功能和社会功能积分与本组治疗前比较均明显好转(P<0.01),治疗组明显优于对照组(P<0.01);治疗组治疗后血清NO、PT水平较治疗前均明显下降(P<0.01),血清GSH-Px、SOD、HGB、PLT及FIB水平较治疗前均明显升高(P<0.01),且治疗组明显优于对照组(P<0.01);治疗组出血停止时间明显短于对照组(P<0.01)。结论中药保留灌肠能够改善AHRE的氧化应激指标、凝血功能和贫血状态,提高肿瘤患者的生存质量,疗效显著。

Objective： To observe the clinical efficacy and nursing experience of retention enema with Chinese herbal medicine on oxidative stress and coagulation function in patients with acute hemorrhagic enteritis. Meth- ods： 64 patients with acute hemorrhagic radiation enteritis were divided into the control group（32 cases） and the treatment group （32 cases） randomly. The control group were treated with compound glutamin entersoluble cap- sules and patients in the treatment group were nursed with retention enema with Chinese herbal medicine. The following data was observed： the changes of quality of life index （SF-36）,oxidative stress index （NO,GSH-Px, SOD） and coagulation function （HGB, FIB,PT,PLT） before and after treatment, and the clinical efficacy of the two group was evaluated. Results： The total effective rate was 84.38% in the control group and 96.88% in the treatment group. The treatment group was significantly better than the control group （P〈 0.01 ）. After treatment,the scores of emotional function ,physical function ,role function ,cognitive function and social function in the treat- ment group were significantly improved compared with those before the treatment （P〈 0.01 ）,and the treatment group was obviously better than the control group （P〈 0.01 ）. The levels of serum NO and PT in the treatment group were significantly lower than those before treatment （P〈 0.01）,and the levels of serum GSH-Px,SOD, HGB,PLT and FIB were significantly higher than those before treatment （P〈 0.01 ）,and the treatment group was obviously better than the control group （P〈 0.01 ）. The bleeding cessation time of the treatment group was lower than that of the control group （P〈 0.01 ）. Conclusion： Retention enema of Chinese herbal medicine can regulate the oxidative stress index, coagulation function and anemia status of patients with AHRE, and improve the quality of life of cancer patients, with a remarkable curative effect.