副乳腺癌23例临床病理特点及预后分析

Clinical characteristics and prognosis of 23 accessory breast cancer cases

目的副乳腺癌是一种罕见且预后较差的恶性肿瘤。本研究通过探讨副乳腺癌的临床病理特点以及预后情况,以提高对该病的认识。方法回顾性的分析新疆医科大学附属肿瘤医院1992-03-01-2016-12-31经病理确诊为副乳腺癌的23例患者以及同期经系统抽样的276的常规乳腺癌临床病理资料,分析两者的临床病理特点及预后情况。结果两组患者就诊时肿块大小(χ~2=4.752,P=0.029)、淋巴结转移率(χ~2=13.894,P<0.001)、临床分期(χ~2=19.978,P<0.001)、术后接受放射治疗(χ~2=33.729,P<0.001)和复发或远处转移率(χ~2=65.359,P<0.001)相比较差异均有统计学意义,副乳腺癌的10年总生存率和10年无病生存率与常规乳腺癌相比均偏低,χ~2值分别为21.37和27.71,均P<0.001。结论副乳腺癌诊断主要依靠临床表现,影像学检查和病理结果,治疗应遵循以手术为主的综合治疗原则。早期发现,早期诊断,早期治疗是提高副乳腺癌预后的关键。

OBJECTIVE Accessory breast cancer is a rare malignancy,and the prognosis is poor.This study aimed to study the clinical characteristics and prognosis of accessory breast cancer.METHODS A retrospective analysis of 23 cases pathologically diagnosed accessory breast cancer and 276 cases of breast cancer were carried out in Tumor Hospital Affiliated to Xinjiang Medical University form March 1,1992 to December 31,2016.The clinical features and the prognosis were analyzed.RESULT There were statistically significant differences in tumor mass（χ^2=4.752,P=0.029）,lymph node metastasis rate（χ^2=13.894,P〈0.001）,clinical stage（χ^2=19.978,P〈0.001）,postoperative radiotherapy treatment rate（χ^2=33.729,P〈0.001）and recurrence or distant metastasis rate（χ^2=65.359,P〈0.001）.The OS of10 year and the DFS of 10 year were lower than those of conventional breast cancer（χ^2=21.37,P〈0.001;χ^2=27.71,P〈0.001）.CONCLUSIONS Diagnosis of accessory breast cancer is mainly based on clinical manifestations,imaging data and pathological detection.The patients should receive a comprehensive treatment based on surgery.Early detection,early diagnosis,early treatment are the key to improve the prognosis.