自然流产和甲状腺自身抗体的相关性研究

Study on the correlation between spontaneous abortion and thyroid autoantibody

目的探讨自然流产和甲状腺自身抗体的相关性。方法选择浙江省湖州市中心医院妇产科2012年1月—2016年12月原发性流产患者70例作为原发性流产组,复发性流产组患者70例作为复发性流产组,健康体检者70例作为对照组。测定3组血清TSH、FT3、FT4、TPO-Ab、TG-Ab水平。结果复发性流产组患者TA阳性率、TPO-Ab阳性率、TG-Ab阳性率均高于对照组(均P<0.05),复发性流产组患者TA阳性率、TPO-Ab阳性率、TG-Ab阳性率与原发性流产组比较差异无统计学意义(均P>0.05),原发性流产组TG-Ab阳性率高于对照组(P<0.05),TA阳性率、TPO-Ab阳性率与对照组比较差异无统计学意义(均P>0.05)。复发性流产组lg(TPO-Ab)高于对照组(P<0.05),复发性流产组lg(TPO-Ab)和原发性流产组比较差异无统计学意义(P>0.05),原发性流产组lg(TPO-Ab)和对照组比较差异无统计学意义(P>0.05),3组lg(TG-Ab)比较差异无统计学意义(P>0.05)。复发性流产患者中,2次流产组和>2次流产组TA阳性率、TPO-Ab阳性率、TG-Ab阳性率比较差异无统计学意义(均P>0.05)。早期流产组和晚期流产组TA阳性率、TPO-Ab阳性率、TG-Ab阳性率比较差异无统计学意义(均P>0.05)。原发性流产组和继发性流产组TA阳性率、TPO-Ab阳性率、TG-Ab阳性率比较差异无统计学意义(均P>0.05)。结论复发性流产患者血清TA、TPO-Ab、TG-Ab阳性率和水平升高,甲状腺自身抗体和复发性流产的发生有关。

Objective To investigate the correlation between spontaneous abortion and thyroid autoantibody. Methods Seventy cases of primary abortion were selected as primary abortion group, seventy cases of recurrent miscarriage were se- lected as recurrent miscarriage group treated in department of Obstetrics and Gynecology of Central Hospital of Huzhou, and seventy cases of healthy subjects were selected as control group from January, 2012 to December, 2016. The serum TSH, FrI3, FT4, TPO-Ab, TG-Ab levels were determined. Results The positive rate of TA, TPO-Ab and TG-Ab in patients of recurrent spontaneous abortion group were higher than those in control group （ P 〈 0.05 ）. There were no sig- nificant difference in the positive rate of TA, TPO-Ab and TG-Ab between recurrent spontaneous abortion group and the primary abortion group （P 〉 0.05）. The positive rate of TG-Ab in primary abortion group was higher than that in control group （P 〈 0.05） ; the positive rate of TA and TPO-Ab showed no significant difference compared with the control group （ P 〉 0.05 ）. The lg （TPO-Ab） in the recurrent abortion group was higher than that in the control group （ P 〈 0.05 ）. There was no significant difference in the lg （TPO-Ab） between recurrent abortion group and primary abortion group （P 〉 0.05 ）. There was no significant difference in the lg （TPO-Ab） between the primary abortion group and the control group （P 〉 0.05 ）. There was no significant difference in lg （TG-Ab） among three groups （ P 〉 0.05 ）. In the recurrent abortion patients, there was no significant difference in TA, TPO-Ab and TG-Ab positive rate between secondary abortion group and secondary abortion group （P 〉 0.05） ; there was no significant difference in TA, TPO-Ab and TG-Ab positive rate between early abortion group and advanced abortion group （P 〉 0.05 ）. There was no significant difference in TA, TPO-Ab and TG-Ab positive rates between primary abortion group and secondary abortion group （P 〉 0. 05 ）. Conclusion The positive rate and levels of serum TA, TPO-Ab and TG-Ab in patients with recurrent spontaneous abor- tion increase. Thyroid autoantibody is related to recurrence abortion.