醋酸氯地孕酮的临床应用进展

Progress on clinical applications of chlormadinone acetate

作为17-α-羟孕酮衍生物,醋酸氯地孕酮(chlormadinone acetate,CMA)具有较强的孕激素活性、抗雌激素活性及较弱的糖皮质激素活性,无雄激素活性及抗盐皮质激素活性。其与炔雌醇(ethinylestradiol,EE)组成的复方口服避孕药在欧洲、拉美等国家广泛应用。除主要用于避孕外,CMA还兼具治疗痛经、雄激素过剩相关疾病(痤疮、脂溢性皮炎、女性型脱发、多毛症、良性前列腺增生)及改善经前或经期不适等非避孕益处。本文就CMA的上述临床应用进展作一综述,为其今后在临床上发挥更充分而合理的应用提供依据。

As a 17α-Hydroxyprogesterone derivative, chlormadinone acetate （CMA） exerts a potent progestagenic effect, anti-estrogen effect and a mild glucosteroidal effect, showing noandrogenic effect and anti- mineralocorticoid effect. It is widely used for oral contraception combined with ethinylestradiol （EE） in Europe, Latin America and other countries. Except for the main use of contraception, it also has many non-contraceptive benefits for dysmenorrhea, androgen excess related diseases （such as acne, seborrheic dermatitis, female hair loss, hirsutism and benign prostatic hyperplasia） and improvement of premenstrual or menstrual discomfort. This article gives a review on the above clinical applications of CMA, so as to provide the evidence for its further and reasonable application in clinical treatment.