了哥王化学成分与生物活性研究进展

Research progress on chemical constituents and biological activities of Wikstroemia indica

了哥王Wikstroemia indica为瑞香科荛花属植物。研究发现了哥王中含有酸类、醇或酯类、醌类、甾体类、香豆素类、木脂素类、黄酮类、萜类、二芳基庚烷类等化合物,具有抗菌、抗病毒、细胞毒、抗炎等活性,主要以香豆素类、黄酮类、醌类和木脂素类成分为对象对了哥王进行含量测定及质量评价。此外,了哥王作为一种有毒中药,通过炮制方法可以降低其毒性,但是其化学成分与药理活性的的关系尚需进一步的研究。对国内外2010—2017年有关了哥王化学成分、生物活性及其成分检测等方面的研究进行归纳总结,以期为其深入研究和开发利用提供参考。

Wikstroemia indica as a Chinese herbal medicine, belonging to family Thymelaeaceae, was the root and root bark of the plant. Studies found that W. indica had acids, alcohols or esters, quinones, steroids, coumarins, lignans, flavonoids, terpenes, diarylheptanes, and fat-soluble ingredients, and has the effects of antibacterial, anti-virus, cytotoxic, and anti-inflammatory activities etc. The contents of coumarins, flavonoids, quinines, and lignans were measured and applied quality evaluation. In addition, as a toxic Chinese herbal medicine, the toxicity of W. indica could be reduced by processing methods, so further research is needed to confirm the relationship between the compound and its pharmacological activity. In this paper, the researches from 2010 to 2017 on chemical constituents, biological activities, and components detection of W. indica were collected and summarized, aiming to provide reference for further research and development on W. indica.