肠道微生态与糖尿病的关系及研究进展

Association of intestinal microecological environments with diabetes mellitus and the research progress

糖尿病发病率逐年升高,其高发病率和致残率已经严重威胁人类健康。肠道微生态作为人体微生态系统的重要组成部分之一,它辅助人体进行营养物质的转化与吸收,并与多个组织、器官存在密切的相互作用,是人体健康的重要保障。近年来利用宏基因组学和生物信息学技术对不同疾病人群的肠道微生态结构和特征进行分析表明,人体健康与肠道微生态存在密切而复杂的联系。而肠道微生态与糖尿病的发生和发展程度也有很大关系。笔者主要就肠道微生态和糖尿病之间的复杂机制及研究进展进行综述。

The incidence of diabetes is rising with years, and its high morbidity and disability rates have seriously threatened human health. As one of the important components of human microecosystem, intestinal microecological system helps the human body to transform and absorb nutrients and has close reciprocities with many tissues and organs, so it is an important guarantee for human health. In recent years, the intestinal microecological structure and characteristics of populations with different diseases have been analyzed by using techniques of macrogenomics and bioinformatics, which revealed that there is a close and complex relationship between human health and the intestinal microecological profile. There is also a strong relationship between intestinal microecological profile and the occurrence and development of diabetes mellitus. Here, the authors mainly address the complex link of intestinal microecological environments to diabetes mellitus and the research progress.