摘要
Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails（Zhang and Reinberg,2001）.It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development（Fischle et al.,2005）.
Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails（Zhang and Reinberg,2001）.It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development（Fischle et al.,2005）.
基金
supported by the National Natural Science Foundation of China(Nos.31540033 and91131002)
the Precision Medicine Research Program of the Chinese Academy of Sciences(KJZD-EW-L14)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12020343)
the National Basic Research Program of China(2013CB911001 and 2012CB518302)
the National Excellent Youth Science Foundation of China(No.31222030)
