摘要
In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood(e.g.,~20 folds for a mouse).Considering the fact that the liver-to-body weight ratio(LBR)stays relatively constant within species(Weglarz and Sandgren,2000;Kan et al.,2009),the cell number in a liver must therefore keep increasing along with the growth of an individual organism. For example, during the growth of the zebrafish from 5 days post-fertilization (dpf) to 1.5 years old, the number of liver cells increased -900 folds (Figs. 1A and S1 ).
In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood(e.g.,~20 folds for a mouse).Considering the fact that the liver-to-body weight ratio(LBR)stays relatively constant within species(Weglarz and Sandgren,2000;Kan et al.,2009),the cell number in a liver must therefore keep increasing along with the growth of an individual organism. For example, during the growth of the zebrafish from 5 days post-fertilization (dpf) to 1.5 years old, the number of liver cells increased -900 folds (Figs. 1A and S1 ).
基金
financially supported by the grants from the National Natural Science Foundation of China(No.31330050)
the National Basic Research Program of China(2015CB942802 and2017YFA0504501)